Blar i forfatter "Eike, Liv-Marie"

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    • Activity of short lytic anticancer peptides against human head and neck cancer cells in vitro 

      Eike, Liv-Marie (Master thesis; Mastergradsoppgave, 2013-06-05)
      Squamous cell carcinoma of the head and neck (head and neck cancer) accounts for over 95% of all cancers of the oral cavity, oropharynx, larynx and hypopharynx [1] and it is the 6th most common cancer disease worldwide. It is the cause of 550 000 cancer deaths annually, the majority of these in the lesser developed world. [2] Treatment options are surgery, radiotherapy and chemotherapy. [1] There ...

    • The cytolytic amphipathic β(2,2)-amino acid LTX-401 induces DAMP release in melanoma cells and causes complete regression of B16 melanoma 

      Eike, Liv-Marie; Mauseth, Brynjar; Camilio, Ketil Andre; Rekdal, Øystein; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      In the present study we examined the ability of the amino acid derivative LTX-401 to induce cell death in cancer cell lines, as well as the capacity to induce regression in a murine melanoma model. Mode of action studies in vitro revealed lytic cell death and release of danger-associated molecular pattern molecules, preceded by massive cytoplasmic vacuolization and compromised lysosomes in treated ...

    • The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells 

      Eike, Liv-Marie; Yang, Nannan; Rekdal, Øystein; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-13)
      Host defense peptides (HDPs) are naturally occurring molecules found in most species, in which they play a significant role in the first line defense against intruding pathogens, and several HDPs have been shown to possess anticancer activity. Structure-activity relationship studies on the HDP bovine lactoferricin revealed a de novo design of a nonamer peptide LTX-315, with oncolytic properties. In ...